2 | Albert Fradera Sola

ZNF524 directly interacts with telomeric DNA and supports telomere integrity

Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they consist of TTAGGG repeats, which are bound by …

Hanna Braun, Ziyan Xu, Fiona Chang, Nikenza Viceconte, Grishma Rane, Michal Levin, Liudmyla Lototska, Franziska Roth, Alexia Hillairet, Albert Fradera Sola, Vartika Khanchandani, Zi Wayne Sin, Wai Khang Yong, Oliver Dreesen, Yang Yang, Yunyu Shi, Fudong Li, Falk Butter, Dennis Kappei

Characterization of two novel proteins involved in mitochondrial DNA anchoring in Trypanosoma brucei

Trypanosoma brucei is a single celled eukaryotic parasite in the group of the Kinetoplastea. The parasite harbors a single …

Simona Amodeo, Irina Bregy, Anneliese Hoffmann, Albert Fradera Sola, Mara Kern, Hélène Baudouin, Benoît Zuber, Falk Butter, Torsten Ochsenreiter

DNA damage repair proteins across the Tree of Life

Genome maintenance is orchestrated by a highly regulated DNA damage response with specific DNA repair pathways. Here, we investigate …

Emily Nischwitz, Vivien A.C. Schoonenberg, Albert Fradera Sola, Mario Dejung, Olga Vydzhak, Michal Levin, Brian Luke, Falk Butter, Marion Scheibe

RNA-dependent interactome allows network-based assignment of RNA-binding protein function

Mass spectrometry-based proteomics data was analyzed to characterize novel interactors for RNA-binding proteins. Network and systems biology strategies revealed concurrent interaction binding patterns and novel functionalities for such proteins.

Albert Fradera Sola, Emily Nischwitz, Marie Elisabeth Bayer, Susanne Kramer, Katja Luck, Falk Butter

RNA-dependent interactome allows network-based assignment of RNA-binding protein function

A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodeling

ChIP-Seq data was analyzed to characterize the novel SNF2 ATPase in Trypanosoma brucei. Differential H2A.Z deposition was detected after RNAi depletion (against no depletion control) and visualized with genome tracks.

Tim Vellmer, Laura Hartleb, Albert Fradera Sola, Susanne Kramer, Elisabeth Meyer-Natus, Falk Butter, Christian J. Janzen

A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodeling

The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1

RNA-Seq data was analyzed to characterize two novel telomere binding proteins (TEBP-1 and TEBP-2). Differential gene expression was investigated on KO worms (against a control strain).

Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera Sola, Christian Renz, Alejandro Ceron Noriega, Helle D. Ulrich, Dennis Kappei, René F. Ketting, Falk Butter

A comparison of shared patterns of differential gene expression and gene ontologies in response to water-stress in roots and leaves of four diverse genotypes of Lolium and Festuca spp. temperate pasture grasses

The previously developed jury vote RNA-Seq differential expression assessment scoring function is now expanded to 4 genotypes, under water streess conditions (leaf and root tissues)

Yuan Fu, Ann Thomas, Dagmara Gasior, John Harper, Alan Gay, Charlotte Jones, Matthew Hegarty, Torben Asp, Albert Fradera Sola, Ian Armstead, Narcis Fernandez-Fuentes

Characterization of the novel mitochondrial genome segregation factor TAP110 in Trypanosoma brucei

The protein of interest was investigated using mass spectrometry based quantitative proteomcis, under native and overexpressed conditions. The experimental method and following analysis were based on a label-free quantification approach.

Simona Amodeo, Ana Kalichava, Albert Fradera Sola, Eloïse Bertiaux-Lequoy, Paul Guichard, Falk Butter, Torsten Oschsenreiter

PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells

SILAC TERRA pulldowns were analyzed for human and murine cell lines. Enriched proteins were functionally analyzed with GO terms.

Nikenza Viceconte, Axelle Loriot, Patricia Lona Abreu, Marion Scheibe, Albert Fradera Sola, Falk Butter, Charles De Smet, Claus M. Azzalin, Nausica Arnoult, Anabelle Decottignies

Differential gene expression and gene ontologies associated with increasing water-stress in leaf and root transcriptomes of perennial ryegrass (Lolium perenne)

A jury vote style scoring function to assess differential gene expression in RNA-Seq data is applied to root and leaf Lolium perenne tissues under different water stress conditions.

Albert Fradera Sola, Ann Thomas, Dagmara Gasior, John Harper, Matthew Hegarty, Ian Armstead, Narcis Fernandez-Fuentes

Differential gene expression and gene ontologies associated with increasing water-stress in leaf and root transcriptomes of perennial ryegrass (Lolium perenne)