Albert Fradera Sola

Albert Fradera Sola

Postdoctoral researcher

Friedrich-Loeffler-Institut

About

I am a postdoctoral researcher in Proteomics and Systems Biology at the Institute of Molecular Virology and Cell Biology of the Friedrich-Loeffler-Institut. My research interests focus on bioinformatics, especially omics data and its statistical analysis. My work revolves around analyzing NGS-based genomics and quantitative mass spectrometry-based proteomics data. I consider myself both collaborative and adaptable. I am always eager to tackle new and different projects. I am very enthusiastic about sharing and developing my data visualization skills as a means towards better science communication. I am an open-minded person and enjoy fostering great relationships with my colleagues.

Download my curriculum vitae.

Interests
  • Bioinformatics
  • Data visualization
  • Proteomics
  • Next generation sequencing
  • Network & Systems biology
Education

  • PhD Candidate in Quantitative Proteomics, 2024

    JGU University

  • M.Sc. in Omics Data Analysis, 2017

    University of Vic

  • B.Sc. in Biochemistry, 2016

    University of Barcelona

Skills

R

Advanced

tidyverse
Data wrangling

Advanced

Data analysis and statistics

Good

ggplot2
Data visualization

Advanced

rmarkdown
Data reporting

Advanced

Shiny
App development

Good

Bash and HPC

Good

MQ
MaxQuant

Good

Python

Beginner

Experience

 
 
 
 
 
Postdoctoral researcher
Friedrich-Loeffler-Institut - Institute of Molecular Virology and Cell Biology
Apr 2023 – Present Greifswald, Germany

In brief:

  • Postdoctoral researcher with Dr. Falk Butter
  • Genomics (RNAseq, ChIPseq) and proteomics data management, analysis and integration
  • Project 1: Developmental proteome quantification in Xenopus species
  • Project 2: Leishmania infectome characterization
 
 
 
 
 
PhD candidate
Institue of Molecular Biology - Johannes Gutenberg Universität
Nov 2018 – Jan 2024 Mainz, Germany

In brief:

  • PhD candidate with Dr. Falk Butter
  • Genomics (RNAseq, ChIPseq) and proteomics data management, analysis and integration
  • Project 1: Characterization of the RNA binding proteins interactome in yeast
 
 
 
 
 
Research assistant
Institue of Molecular Biology - Johannes Gutenberg Universität
Feb 2018 – Sep 2018 Mainz, Germany

In brief:

  • Research assistant with Dr. Falk Butter
  • Genomics (RNAseq, ChIPseq) data management, analysis and integration
 
 
 
 
 
Master student
Institute of Biological, Environmental and Rural Sciences - Aberystwyth university
Apr 2017 – Oct 2017 Aberystwyth, UK

In brief:

  • MSc student with Dr. Narcs Fernandez-Fuentes
  • Development of a scoring function for assessing transcriptome differential expression on Lolium Perenne
 
 
 
 
 
Bachelor student
Max Perutz laboratories - Universität Wien
Sep 2015 – Mar 2016 Vienna, Austria

In brief:

  • B.Sc. student with Dr. Robert Konrat
  • Recording and analysis of NMR spectroscopic data

Accomplish­ments

Coursera
See certificate
Coursera
See certificate

Projects

*
All Proteomics Genomics Miscellaneous
Interactive CV network
Do you want to make your CV shine? Learn how to create a network plot (as an image or as an interactive .html) based on the entries on a standard CV with a tutorial based on my own résumé.
Interactive CV network
Network-based assignment of RNA-binding protein function
In my main PhD project, I focused on RNA binding proteins (RBPs) and their role in RNA pathways. To better understand their functions, we selected RBPs based on their known involvement in these pathways and immunoprecipitated them. Through this approach, we were able to create a function-based network that allowed us to assign new functionalities to both known and novel RBPs. Our work on this project was recently presented at CSAMA 2022.
Slides
Network-based assignment of RNA-binding protein function
Scoring function development for RNA-Seq differential expression assessment
For my M.Sc project, I developed a scoring function to evaluate the performance of four widely used RNA-Seq differential expression packages (DESeq2, edgeR, limma+voom, and BaySeq). The aim was to compare and assess the results of each package and determine the optimal approach for detecting differentially expressed genes (DEGs). By developing this function, we aimed to provide researchers with a tool to maximize or restrict the number of detected DEGs based on their criteria.
PDF Slides
Scoring function development for RNA-Seq differential expression assessment

Featured Publications

Albert Fradera Sola, Emily Nischwitz, Marie Elisabeth Bayer, Susanne Kramer, Katja Luck, Falk Butter
April, 2023 In Nucleic Acids Research
RNA-dependent interactome allows network-based assignment of RNA-binding protein function
RNA-dependent interactome allows network-based assignment of RNA-binding protein function

Mass spectrometry-based proteomics data was analyzed to characterize novel interactors for RNA-binding proteins. Network and systems biology strategies revealed concurrent interaction binding patterns and novel functionalities for such proteins.
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Albert Fradera Sola, Ann Thomas, Dagmara Gasior, John Harper, Matthew Hegarty, Ian Armstead, Narcis Fernandez-Fuentes
July, 2019 In PLoS ONE
Differential gene expression and gene ontologies associated with increasing water-stress in leaf and root transcriptomes of perennial ryegrass (Lolium perenne)
Differential gene expression and gene ontologies associated with increasing water-stress in leaf and root transcriptomes of perennial ryegrass (Lolium perenne)

A jury vote style scoring function to assess differential gene expression in RNA-Seq data is applied to root and leaf Lolium perenne tissues under different water stress conditions.
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Publications

Simona Amodeo, Irina Bregy, Anneliese Hoffmann, Albert Fradera Sola, Mara Kern, Hélène Baudouin, Benoît Zuber, Falk Butter, Torsten Ochsenreiter (2023). RNA-dependent interactome allows network-based assignment of RNA-binding protein function. In PLoS Pathogens.

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Emily Nischwitz, Vivien A.C. Schoonenberg, Albert Fradera Sola, Mario Dejung, Olga Vydzhak, Michal Levin, Brian Luke, Falk Butter, Marion Scheibe (2023). DNA damage repair proteins across the Tree of Life. In iScience.

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Albert Fradera Sola, Emily Nischwitz, Marie Elisabeth Bayer, Susanne Kramer, Katja Luck, Falk Butter (2023). RNA-dependent interactome allows network-based assignment of RNA-binding protein function. In Nucleic Acids Research.

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Tim Vellmer, Laura Hartleb, Albert Fradera Sola, Susanne Kramer, Elisabeth Meyer-Natus, Falk Butter, Christian J. Janzen (2022). A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodeling. In PLoS Pathogens.

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Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera Sola, Christian Renz, Alejandro Ceron Noriega, Helle D. Ulrich, Dennis Kappei, René F. Ketting, Falk Butter (2021). A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodelling. In Nature Communications.

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Yuan Fu, Ann Thomas, Dagmara Gasior, John Harper, Alan Gay, Charlotte Jones, Matthew Hegarty, Torben Asp, Albert Fradera Sola, Ian Armstead, Narcis Fernandez-Fuentes (2021). A comparison of shared patterns of differential gene expression and gene ontologies in response to water-stress in roots and leaves of four diverse genotypes of Lolium and Festuca spp. temperate pasture grasses. In PLoS ONE.

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Simona Amodeo, Ana Kalichava, Albert Fradera Sola, Eloïse Bertiaux-Lequoy, Paul Guichard, Falk Butter, Torsten Oschsenreiter (2021). Characterization of the novel mitochondrial genome segregation factor TAP110 in Trypanosoma brucei. In Journal of Cell Science.

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Nikenza Viceconte, Axelle Loriot, Patricia Lona Abreu, Marion Scheibe, Albert Fradera Sola, Falk Butter, Charles De Smet, Claus M. Azzalin, Nausica Arnoult, Anabelle Decottignies (2020). PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells. In RNA.

PDF Cite DOI

Albert Fradera Sola, Ann Thomas, Dagmara Gasior, John Harper, Matthew Hegarty, Ian Armstead, Narcis Fernandez-Fuentes (2019). Differential gene expression and gene ontologies associated with increasing water-stress in leaf and root transcriptomes of perennial ryegrass (Lolium perenne). In PLoS ONE.

PDF Cite Project DOI

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